Single Use Event 2020
Single Use Event 2020

What makes your product/innovation/process unique?
 

Nico Oosterhuis

Director Technology at Celltainer Biotech
Celltainer Biotech BV provides multi-purpose single-use bioreactors at three different scales: 2 L, 20 L and 200 L. The reactor is a rocking platform, but based on a 2-dimensional motion, providing besides the ‘traditional’ rocking motion, a horizontal translation as well. As a result, at high rocking speeds and at a larger angle, the CELL-tainer® provides a high kLa, which makes the equipment very well suited for microbial, fungi and yeast processes.
However, at restricted rocking speeds and smaller angles, the mixing and mass transfer are still far better than traditional stirred bioreactors for cell culture purposes and traditional rocking bioreactors. This ensures sufficient G/L mass transfer to support high cell densities at low shear rates. 

For cultivating stem cells or satellite cells for production of cultured meat, but also for propagation of plant cells or even embryonic plant cells for somatic embryogenesis, this reactor type is very well suited. The systems are linearly scalable and thus providing a scalable production platform technology to produce cellular agricultural products.
The CELL-tainer® presently is applied in biopharma applications and more traditional fermentation processes (like amino acids, food enzymes and starter cultures, etc.) and we foresee a further expansion in the cellular agriculture.

What does the future hold?

 

Most important/significant development? The introduction of single-use technologies in general, but now also in more traditional processes for seeding.
Upcoming trends? Application in cellular agriculture.
Most important unsolved challenge? For cultured meat the production costs are still far too high. Most important are costs of media, but also volumetric productivity is a major cost driver.

 

 

 

 

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